Bayesian Materia Medica of selected medicines

Criteria for validating indicating symptoms:

• At least 2 cases of the medicine with the symptom.

• Moderate or high statistical certainty (cumulative binomial probability >0.9)

Criteria for validating keynote symptoms:

• Prevalence in the medicine population >7%

• LR >3

Criteria for validating contra-indicating symptoms:

• High statistical certainty (cumulative binomial probability <0.05)

Why do we use cumulative binomial probability (CBP) for symptoms' statistical validation? Read here